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Article

Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.

Nucleic acids research - 15 Nov 2001

Selfridge J, Hsia K T, Redhead N J, Melton D W

Abstract excerpt

The ERCC1 gene is essential for the repair of UV-induced DNA damage. Unlike most genes in the nucleotide excision repair (NER) pathway, ERCC1 is also involved in recombinational repair. Perhaps for this reason, ERCC1 knockout mice are not a model for the human NER deficiency disorder, xeroderma pigmentosum. Instead, ERCC1 null mice are severely runted and die before weaning from liver failure with accelerated...

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Identifiers

PMID: 11713303
DOI: 10.1093/nar/29.22.4541
PMCID: PMC92547

Genes

ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.PMID 11713303Read ↗

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