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Article

Loss of Clcc1 results in ER stress, misfolded protein accumulation, and neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Feb 2015

Jia Yichang, Jucius Thomas J, Cook Susan A, Ackerman Susan L

Abstract excerpt

Folding of transmembrane and secretory proteins occurs in the lumen of the endoplasmic reticulum (ER) before transportation to the cell surface and is monitored by the unfolded protein response (UPR) signaling pathway. The accumulation of unfolded proteins in the ER activates the UPR that restores ER homeostasis by regulating gene expression that leads to an increase in the protein-folding capacity of the ER and...

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Identifiers

PMID: 25698737
DOI: 10.1523/JNEUROSCI.3678-14.2015
PMCID: PMC4331624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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