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p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

21 Mar 2024

Abstract excerpt

Abstract DNA repair deficiency can lead to segmental phenotypes in humans and mice, in which certain tissues lose homeostasis while others remain seemingly unaffected. This may be due to different tissues facing varying levels of damage or having different reliance on specific DNA repair pathways. However, we find that the cellular response to DNA damage determines different tissue-specific outcomes. Here, we use...

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PMID: 38514641
DOI: 10.1038/s41467-024-46844-1

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