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BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis

23 Apr 2021

Abstract excerpt

Meiosis is a specialized cell cycle that results in the production of haploid gametes for sexual reproduction. During meiosis, homologous chromosomes are connected by chiasmata, the physical manifestation of crossovers. Crossovers are formed by the repair of intentionally induced double strand breaks by homologous recombination and facilitate chromosome alignment on the meiotic spindle and proper chromosome...

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PMID: 33996823
DOI: 10.3389/fcell.2021.668309

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