Article
A new strategy based on recombinant viruses for assessing the replication capacity of HIV-1.
HIV medicine - 1 Mar 2008
Garcia-Perez J, Perez-Olmeda M, Sanchez-Palomino S, Perez-Romero P, Alcami J
Abstract excerpt
OBJECTIVE: In heavily pretreated patients, resistance mutations arise in both protease (PR) and reverse transcriptase (RT) sequences; however, the relative impact of PR and RT mutations on viral fitness cannot be evaluated with the majority of systems. To address this issue we have developed a model based on recombinant viruses (RVs) that allows the analysis of the replication capacity (RC) of viral populations...
Topics
- Antiretroviral Therapy, Highly Active
- Drug Resistance, Multiple, Viral
- Genes, Reporter
- Genetic Vectors
- Genotype
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Luciferases, Renilla
- Mutation