Article
Quantitative evaluation of the recombinant HIV-1 phenotype to protease inhibitors by a single-step strategy.
AIDS (London, England) - 16 Jun 2000
Menzo S, Rusconi S, Monachetti A, Colombo M C, Violin M, Bagnarelli P, Varaldo P E, Moroni M, Galli M, Balotta C, Clementi M
Abstract excerpt
OBJECTIVE: To develop and optimize a fast and quantitative recombinant strategy for evaluating the HIV-1 phenotype to protease inhibitors (PI). DESIGN AND METHODS: A non-replicative HIV-1 molecular vector (designated pdelta prodelta env) capable of expressing exogenous HIV-1 protease-encoding sequences was developed in this study. The HIV-1 protease sequences were amplified from either viral isolates or plasma...
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