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Article

Novel recombinant phenotypic assay for clonal analysis of reverse transcriptase mutations conferring drug resistance to HIV-1 variants.

The Journal of antimicrobial chemotherapy - 1 May 2004

Paolucci Stefania, Baldanti Fausto, Zavattoni Maurizio, Gerna Giuseppe

Abstract excerpt

OBJECTIVE: A novel rapid reverse transcriptase (RT) recombinant HIV-1 drug-susceptibility assay was developed to evaluate resistance to RT inhibitors. MATERIAL AND METHODS: HIV-1 RTs from five treatment-naive and 10 highly active antiretroviral therapy-experienced patients were evaluated. HIV-1 isolates recovered by culturing peripheral blood mononuclear cells from patients were used in the conventional isolate...

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Share to Antiretroviral Therapy, Highly Active
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Reverse Transcriptase

Share to Recombination, Genetic

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Viral

Share to Treatment Failure

Source

Identifiers

PMID: 15044427
DOI: 10.1093/jac/dkh165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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