Article
Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates.
Antimicrobial agents and chemotherapy - 1 Jan 1994
Kellam P, Larder B A
Abstract excerpt
Antiviral drug susceptibility assays for clinical human immunodeficiency virus type 1 (HIV-1) isolates are required to monitor the development of drug resistance during clinical trials and antiretroviral drug therapy. First-generation phenotypic assays possess a number of drawbacks, not least the...
Topics
- Antiviral Agents
- Base Sequence
- CD4 Antigens
- Cell Line
- DNA, Viral
- Genotype
- HIV Infections
- HIV-1
- HeLa Cells
- Humans
- Lymphocytes
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Recombination, Genetic
- Viral Plaque Assay
- Virus Replication