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Article

A237T as a modulating mutation in naturally occurring extended-spectrum TEM-type beta-lactamases.

Antimicrobial agents and chemotherapy - 1 May 1998

Blázquez J, Negri M C, Morosini M I, Gómez-Gómez J M, Baquero F

Abstract excerpt

A TEM-1 beta-lactamase derivative containing the single amino acid substitution A237T slightly increased (from 24 to 32 microg/ml) the cephalothin MIC for Escherichia coli RYC1000 but did not influence the activities of cefotaxime, ceftazidime, and aztreonam (MICs of 0.03, 0.12, and 0.06 microg/ml, respectively). Despite its apparent neutrality, addition of the A237T mutation to the pair of mutations...

Topics

Escherichia coli
Genes, Bacterial
Microbial Sensitivity Tests
Mutagenesis, Site-Directed
Phenotype
beta-Lactam Resistance
beta-Lactamases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9593123
DOI: 10.1128/AAC.42.5.1042
PMCID: PMC105741

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A237T as a modulating mutation in naturally occurring extended-spectrum TEM-type beta-lactamases.PMID 9593123Read ↗

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