Article
Experimental prediction of the evolution of ceftazidime resistance in the CTX-M-2 extended-spectrum beta-lactamase.
Antimicrobial agents and chemotherapy - 1 Mar 2005
Welsh Kerry J, Barlow Miriam, Tenover Fred C, Biddle James W, Rasheed J Kamile, Clark Leigh Ann, McGowan John E
Abstract excerpt
We applied in vitro evolution to an Escherichia coli strain containing bla(CTX-M-2) and obtained 10 independent mutant bla(CTX-M-2) alleles that confer elevated resistance to ceftazidime (MIC > or = 32 microg/ml) but lost the ability to confer resistance to cefepime. All alleles had a Pro-to-Ser substitution at position 167.
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