Article
Molecular evolution of ubiquitous beta-lactamases towards extended-spectrum enzymes active against newer beta-lactam antibiotics.
Molecular microbiology - 1 Oct 1990
Collatz E, Labia R, Gutmann L
Abstract excerpt
Production of beta-lactamases, and of the plasmid-encoded TEM- and SHV-type enzymes in particular, is the most common mechanism of resistance against beta-lactam antibiotics in Gram-negative bacteria. The two ubiquitous types of enzyme have a large spectrum of activity and preferentially hydrolyse the penicillins as well as some first- and second-generation cephalosporins. Recently, point mutations in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.