Molecular evolution of ubiquitous beta-lactamases towards extended-spectrum enzymes active against newer beta-lactam antibiotics.

doi:10.1111/j.1365-2958.1990.tb00537.x

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Article

Molecular evolution of ubiquitous beta-lactamases towards extended-spectrum enzymes active against newer beta-lactam antibiotics.

Molecular microbiology - 1 Oct 1990

Collatz E, Labia R, Gutmann L

Abstract excerpt

Production of beta-lactamases, and of the plasmid-encoded TEM- and SHV-type enzymes in particular, is the most common mechanism of resistance against beta-lactam antibiotics in Gram-negative bacteria. The two ubiquitous types of enzyme have a large spectrum of activity and preferentially hydrolys...

Topics

Amino Acid Sequence
Amino Acids
Anti-Bacterial Agents
Drug Resistance, Microbial
Genes, Bacterial
Gram-Negative Bacteria
Molecular Sequence Data
Mutation
beta-Lactamases
beta-Lactams

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