Article
Very low cefotaxime concentrations select for hypermutable Streptococcus pneumoniae populations.
Antimicrobial agents and chemotherapy - 1 Feb 2002
Negri María-Cristina, Morosini María-Isabel, Baquero María-Rosario, del Campo Rosa, Blázquez Jesús, Baquero Fernando
Abstract excerpt
A mixed culture of an hypermutable hexA Streptococcus pneumoniae mutant strain and its hexA(+) isogenic ancestor was challenged with low cefotaxime concentrations. Despite identical original cefotaxime MICs, the hexA mutant population was significantly selected at very low concentrations, and all of the tested selected variants harbored the Thr550-->Ala mutation in pbp2x. Since cefotaxime selects hypermutators,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.