Article
Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo.
Journal of cell science - 15 Feb 2008
Delacour Delphine, Koch Annett, Ackermann Waltraud, Eude-Le Parco Isabelle, Elsässer Hans-Peter, Poirier Francoise, Jacob Ralf
Abstract excerpt
Epithelial cells are characterised by distinct apical and basolateral membrane domains that are separated by tight junctions. Establishment and maintenance of this polarity depend on specific gene expression and protein targeting to their correct location. Our former studies, performed with renal epithelial MDCK cells, revealed a new function for galectin-3, a member of a conserved family of lectins. There,...
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