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Article

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish.

Nature communications - 6 Jul 2018

Zhao Shaoyang, Xia Jianhong, Wu Xiuhua, Zhang Leilei, Wang Pengtao, Wang Haiyun, Li Heying, Wang Xiaoshan, Chen Yan, Agnetti Jean, Li Yinxiong, Pei Duanqing, Shu Xiaodong

Abstract excerpt

The class III PI3-kinase (PIK3C3) is an enzyme responsible for the generation of phosphatidylinositol 3-phosphate (PI3P), a critical component of vesicular membrane. Here, we report that PIK3C3 deficiency in zebrafish results in intestinal injury and inflammation. In pik3c3 mutants, gut tube forms but fails to be maintained. Gene expression analysis reveals that barrier-function-related inflammatory bowel disease...

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Identifiers

PMID: 29980668
DOI: 10.1038/s41467-018-05105-8
PMCID: PMC6035235

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