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Article

Reduced NHE3-mediated Na+ absorption increases survival and decreases the incidence of intestinal obstructions in cystic fibrosis mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2009

Bradford Emily M, Sartor Maureen A, Gawenis Lara R, Clarke Lane L, Shull Gary E

Abstract excerpt

In cystic fibrosis, impaired secretion resulting from loss of activity of the cystic fibrosis transmembrane conductance regulator (CFTR) causes dehydration of intestinal contents and life-threatening obstructions. Conversely, impaired absorption resulting from loss of the NHE3 Na+/H+ exchanger causes increased fluidity of the intestinal contents and diarrhea. To test the hypothesis that reduced NHE3-mediated...

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Source

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Identifiers

PMID: 19164484
DOI: 10.1152/ajpgi.90520.2008
PMCID: PMC2670667

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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