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Azacytidine treatment affects the methylation pattern of genomic and cell-free DNA in uveal melanoma cell lines

21 Oct 2024

Abstract excerpt

BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular tumour in adults, and approximately 50% of patients will develop metastasis. Epigenetic changes are a major factor in cancer progression. We aimed to determine whether methylation profiles could be altered using a DNA methyltransferase (DNMT) inhibitor in UM cell lines. METHODS: Four primary and metastatic UM cell lines were treated with...

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PMID: 39434038
DOI: 10.1186/s12885-024-13037-4

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