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Azacytidine Treatment Affects Methylation Pattern of Genomic and Cell-Free DNA in Uveal Melanoma Cell Lines

2024-05-14

Abstract excerpt

<title>Abstract</title> <p>Background Uveal melanoma (UM) is the most common primary intraocular tumour in adults, and approximately 50% of patients will develop metastasis. Epigenetic changes are a major factor in cancer progression. We aimed to determine whether methylation profiles could be altered using a DNA methyltransferase (DNMT) inhibitor in UM cell lines. Methods Four primary and metastatic UM cell li...

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Literature Corpus work
7ed6db06-4bec-54cf-9e14-c22df35fc59d
DOI
10.21203/rs.3.rs-4361337/v1
Open publication

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Azacytidine Treatment Affects Methylation Pattern of Genomic and Cell-Free DNA in Uveal Melanoma Cell LinesDOI 10.21203/rs.3.rs-4361337/v1
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