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Article

Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.

The Journal of biological chemistry - 21 Mar 2008

Hurst Douglas R, Xie Yi, Vaidya Kedar S, Mehta Alka, Moore Blake P, Accavitti-Loper Mary Ann, Samant Rajeev S, Saxena Ritu, Silveira Alexandra C, Welch Danny R

Abstract excerpt

The BRMS1 metastasis suppressor interacts with the protein AT-rich interactive domain 4A (ARID4A, RBBP1) as part of SIN3.histone deacetylase chromatin remodeling complexes. These transcriptional co-repressors regulate diverse cell phenotypes depending upon complex composition. To define BRMS1 complexes and their roles in metastasis suppression, we generated BRMS1 mutants (BRMS1(mut)) and mapped ARID4A...

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Identifiers

PMID: 18211900
DOI: 10.1074/jbc.M709446200
PMCID: PMC2293288

Genes

BRMS1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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