Article
Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration.
Vision research - 1 Feb 2008
Chen Haoyu, Yang Zhenglin, Gibbs Daniel, Yang Xian, Hau Vincent, Zhao Peiquan, Ma Xiang, Zeng Jiexi, Luo Ling, Pearson Erik, Constantine Ryan, Kaminoh Yuuki, Harmon Jennifer, Tong Zongzhong, Stratton Charity A, Cameron D Joshua, Tang Shibo, Zhang Kang
Abstract excerpt
Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD. In order to investigate the association of this HTRA1 polymorphism and the bilaterality of AMD, we genotyped rs11200638 in control, unilateral, and bilateral advanced AMD patients. The A allele for SNP rs11200638 in HTRA1, was significantly more prevalent in bilateral wet AMD and GA...
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