A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.

doi:10.1038/s41598-017-07526-9

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Article

A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.

Scientific reports - 3 Aug 2017

Kawashima-Kumagai Kyoko, Yamashiro Kenji, Yoshikawa Munemitsu, Miyake Masahiro, Ming Gemmy Cheung Chui, Fan Qiao, Koh Jia Yu, Saito Masaaki, Sugahara-Kuroda Masako, Oishi Maho, Akagi-Kurashige Yumiko, Nakata Isao, Nakanishi Hideo, Gotoh Norimoto, Oishi Akio, Tamura Hiroshi, Ooto Sotaro, Tsujikawa Akitaka, Kurimoto Yasuo, Sekiryu Tetsuju, Matsuda Fumihiko, Khor Chiea-Chuen, Cheng Ching-Yu, Wong Tien Yin, Yoshimura Nagahisa

Abstract excerpt

Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide association study (GWAS) on bilaterality has been rarely reported. In the present study, we performed GWAS using neovascular AMD cases in East Asian. The discovery...

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Identifiers

PMID: 28775256
DOI: 10.1038/s41598-017-07526-9
PMCID: PMC5543064

Genes

FSHR
LHCGR
STON1
ARMS2
HTRA1
CTNNA3
PLXNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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