Article
The relevance of xenobiotic metabolism in the interindividual susceptibility to chemicals.
Folia histochemica et cytobiologica - 1 Jan 2001
Testai E
Abstract excerpt
Biotransformation enzymes may catalyze either detoxication or bioactivation reactions; indeed, many xenobiotics exert their toxic effects after metabolic activation to electrophilic chemicals, interacting with nucleophilic sites on cellular macromolecules. On the other hand, by increasing xenobiotic hydrophilicity, the drug-metabolizing enzymes favors excretion of lipophilic chemicals, not allowing their...
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