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Article

Genetic variability in susceptibility and response to toxicants.

Toxicology letters - 31 Mar 2001

Miller M C, Mohrenweiser H W, Bell D A

Abstract excerpt

Everyone has a unique combination of polymorphic traits that modify susceptibility and response to drugs, chemicals and carcinogenic exposures. The metabolism of exogenous and endogenous chemical toxins may be modified by inherited and induced variation in CYP (P450), acetyltransferase (NAT) and glutathione S-transferase (GST) genes. We observe that specific 'at risk' genotypes for GSTM1 and NAT1/2 increase risk...

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Source

Identifiers

PMID: 11323185
DOI: 10.1016/s0378-4274(01)00279-x

Genes

GSTM1
NAT1
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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