Article
An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate.
Genetics - 1 Jan 2008
Bismuth Keren, Skuntz Susan, Hallsson Jón H, Pak Evgenia, Dutra Amalia S, Steingrímsson Eiríkur, Arnheiter Heinz
Abstract excerpt
The mouse Mitf gene encodes a transcription factor that is regulated by serine phosphorylation and is critical for the development of melanin-containing pigment cells. To test the role of phosphorylation at a particular serine, S73 in exon 2 of Mitf, we used a standard targeting strategy in mouse embryonic stem cells to change the corresponding codon into one encoding an alanine. By chance, we generated an allele...
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