Article
High-frequency genetic reversion mediated by a DNA duplication: the mouse pink-eyed unstable mutation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993
Gondo Y, Gardner J M, Nakatsu Y, Durham-Pierre D, Deveau S A, Kuper C, Brilliant M H
Abstract excerpt
The mouse pink-eyed unstable (p(un)) mutation, affecting coat color, exhibits one of the highest reported reversion frequencies of any mammalian mutation and is associated with a duplication of genomic DNA at the p locus. In this study, genomic clones containing the boundaries of the p(un) duplication were isolated and characterized. The structure of these sequences and their wild-type and revertant counterparts...
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