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Article

In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.

Genetics - 1 May 2012

Debbache Julien, Zaidi M Raza, Davis Sean, Guo Theresa, Bismuth Keren, Wang Xin, Skuntz Susan, Maric Dragan, Pickel James, Meltzer Paul, Merlino Glenn, Arnheiter Heinz

Abstract excerpt

The microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper protein that plays major roles in the development and physiology of vertebrate melanocytes and melanoma cells. It is regulated by post-translational modifications, including phosphorylation at serine 73, which based on in vitro experiments imparts on MITF an increased transcriptional activity paired with a...

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Identifiers

PMID: 22367038
DOI: 10.1534/genetics.111.135996
PMCID: PMC3338255

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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In vivo role of alternative splicing and serine phosphorylation of the microphthalmia-associated transcription factor.PMID 22367038Read ↗

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Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters.Semantic proximity Read ↗

Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform.Semantic proximity Read ↗

Regional Fluctuation in the Functional Consequence of LINE-1 Insertion in the Mitf Gene: The Black Spotting Phenotype Arisen from the Mitfmi-bw Mouse Lacking Melanocytes.Semantic proximity Read ↗

MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor mRNA is inhibited by the coding region determinant-binding protein.Semantic proximity Read ↗

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An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness.Semantic proximity Read ↗

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