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Article

Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.

Journal of the National Cancer Institute - 3 Nov 2010

Abel Erika L, Angel Joe M, Riggs Penny K, Langfield Laura, Lo Herng-Hsiang, Person Maria D, Awasthi Yogesh C, Wang Li-E, Strom Sara S, Wei Qingyi, DiGiovanni John

Abstract excerpt

BACKGROUND: The incidence of nonmelanoma skin cancer (NMSC) is equivalent to that of all other cancers combined. Previously, we mapped the 12-O-tetradecanoylphorbol-13-acetate (TPA) skin tumor promotion susceptibility locus, Psl1, to distal chromosome 9 in crosses of sensitive DBA/2 mice with relatively resistant C57BL/6 mice. Here, we used the mouse two-stage skin carcinogenesis model to identify the gene(s)...

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Source

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Identifiers

PMID: 20966433
DOI: 10.1093/jnci/djq392
PMCID: PMC2970579

Genes

GSTA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.PMID 20966433Read ↗

Genetics of skin tumor promotion.Semantic proximity Read ↗

Fine mapping reveals that promotion susceptibility locus 1 (Psl1) is a compound locus with multiple genes that modify susceptibility to skin tumor development.Semantic proximity Read ↗

Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.Semantic proximity Read ↗

Identification of novel genetic loci contributing to 12-O-tetradecanoylphorbol-13-acetate skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.Semantic proximity Read ↗

Confirmation of the mapping of a 12-O-tetradecanoylphorbol-13-acetate promotion susceptibility locus, Psl1, to distal mouse chromosome 9.Semantic proximity Read ↗

New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK.Semantic proximity Read ↗

Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.Semantic proximity Read ↗

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma.Semantic proximity Read ↗

Identification of an X-linked locus modifying mouse skin tumor susceptibility.Semantic proximity Read ↗

The interplay between dormant mutated cells and tumor promotion by chronic tissue damage in determining cancer riskSemantic proximity Read ↗

Multigenic control of skin tumor susceptibility in SENCARA/Pt mice.Semantic proximity Read ↗

Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.Semantic proximity Read ↗

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