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Article

Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

6 Jan 2012

Abstract excerpt

Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to study tumorigenesis. Mice lacking Langerhans cells (LCs), a signatory epidermal dendritic cell (DC), are protected from cutaneous chemical carcinogenesis, independent of T cell immunity. Investigation of the underlying mechanism revealed that LC-deficient skin was relatively...

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PMID: 22223807
DOI: 10.1126/science.1211600

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