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Article

The protective role of host Toll-like receptor-4 in acute graft-versus-host disease.

Transplantation - 27 Nov 2010

Imado Takehito, Iwasaki Tsuyoshi, Kitano Sachie, Satake Atsushi, Kuroiwa Takanori, Tsunemi Sachi, Sano Hajime

Abstract excerpt

BACKGROUND: Mutations in Toll-like receptor (TLR)-4 have been associated with the hyporesponsiveness of macrophages to lipopolysaccharide, possibly reducing the risk of acute graft-versus-host disease (GVHD). However, TLR-4 mutations may also increase the risk of intestinal damage and microbial i...

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Source

Identifiers

PMID: 20975627
DOI: 10.1097/TP.0b013e3181f86947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20975627-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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