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Article

Toll-like receptor-4 deficiency enhances repair of UVR-induced cutaneous DNA damage by nucleotide excision repair mechanism.

The Journal of investigative dermatology - 1 Jun 2014

Ahmad Israr, Simanyi Eva, Guroji Purushotham, Tamimi Iman A, delaRosa Hillary J, Nagar Anusuiya, Nagar Priyamvada, Katiyar Santosh K, Elmets Craig A, Yusuf Nabiha

Abstract excerpt

UVB-induced DNA damage has a critical role in the development of photoimmunosuppression. The purpose of this study was to determine whether repair of UVB-induced DNA damage is regulated by Toll-like receptor-4 (TLR4). When TLR4 gene knockout (TLR4(-/-)) and TLR4-competent (TLR4(+/+)) mice were subjected to 90 mJ cm(-2) UVB radiation locally, DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) was...

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Identifiers

PMID: 24326454
DOI: 10.1038/jid.2013.530
PMCID: PMC4020975

Genes

TLR4
XPA
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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