Article
Proteomic and pathway analyses reveal a network of inflammatory genes associated with differences in skin tumor promotion susceptibility in DBA/2 and C57BL/6 mice.
Carcinogenesis - 1 Nov 2012
Shen Jianjun, Abel Erika L, Riggs Penny K, Repass John, Hensley Sean C, Schroeder Lisa J, Temple Angelina, Chau Alexander, McClellan S Alex, Rho Okkyung, Kiguchi Kaoru, Ward Michael D, Semmes O John, Person Maria D, Angel Joe M, Digiovanni John
Abstract excerpt
Genetic susceptibility to two-stage skin carcinogenesis is known to vary significantly among different stocks and strains of mice. In an effort to identify specific protein changes or altered signaling pathways associated with skin tumor promotion susceptibility, a proteomic approach was used to examine and identify proteins that were differentially expressed in epidermis between promotion-sensitive DBA/2 and...
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