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Article

Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.

The Journal of biological chemistry - 14 Mar 2008

Tran Sinh, Norstrøm Eva, Dahlbäck Björn

Abstract excerpt

The factor Va (FVa) inactivation by activated protein C (APC), mediated by cleavages at Arg306 and Arg506 in FVa, is inhibited by both factor Xa (FXa) and prothrombin. Although FXa is known to specifically inhibit the Arg506 cleavage, the effect of prothrombin has not been confined to one cleavage site. We used recombinant FV variants, FV:R506Q/R679Q and FV:R306Q/R679Q, to investigate the effect of prothrombin on...

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Source

Identifiers

PMID: 18198180
DOI: 10.1074/jbc.M708036200

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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