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Article

Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2010

Tran S, Dahlbäck B

Abstract excerpt

BACKGROUND: Activated protein C (APC) inhibits factor Va (FVa) by cleaving at Arg306, Arg506 and Arg679. Protein S serves as cofactor, in particular for the Arg306 site, and a protein S-mediated relocation of the active site of APC closer to the membrane has been proposed as a mechanism. Recently, it was demonstrated that FVa, which was mutated at all three APC-cleavage sites (FVa-306Q/506Q/679Q), could still be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19874463
DOI: 10.1111/j.1538-7836.2009.03657.x

Genes

APC

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Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.PMID 19874463Read ↗

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