Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.

European journal of biochemistry - 1 Feb 1999

Heeb M J, Rehemtulla A, Moussalli M, Kojima Y, Kaufman R J

Abstract excerpt

Activated protein C (APC) cleavage of Factor Va (FVa) at residues R506 and R306 correlates with its inactivation. APC resistance and increased thrombotic risk are due to the mutation R506Q in Factor V (FV). To study the effects of individual cleavages in FVa by APC and the importance of regions near the cleavage sites, the following recombinant (r) human FVs were prepared and purified: wild-type, Q306-rFV,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor V

Share to Factor Xa

Share to Immunoblotting

Share to Protein C

Share to Thrombin

Share to Thromboplastin

Source

Identifiers

PMID: 10091585
DOI: 10.1046/j.1432-1327.1999.00137.x

Genes

APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.PMID 10091585Read ↗

Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.Semantic proximity Read ↗

Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.Semantic proximity Read ↗

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.Semantic proximity Read ↗

Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.Semantic proximity Read ↗

The anticoagulant function of coagulation factor V.Semantic proximity Read ↗

The R306G and R506Q mutations in coagulation Factor V reveals additional cleavage sites for Activated Protein C in the R313-R321 region and at R505.Semantic proximity Read ↗

Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.Semantic proximity Read ↗

Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.Semantic proximity Read ↗

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.Semantic proximity Read ↗

Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.Semantic proximity Read ↗

Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders.Semantic proximity Read ↗

Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.