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Article

Hyperprothrombinaemia-induced APC resistance: differential influence on fibrin formation and fibrinolysis.

Thrombosis and haemostasis - 1 Apr 2006

Binetti Bianca M, Rotunno Crescenza, Tripodi Armando, Asti Daniela, Semeraro Fabrizio, Semeraro Nicola, Colucci Mario

Abstract excerpt

The prothrombin gene mutation G20210A is a common risk factor for thrombosis and has been reported to cause APC resistance. However, the inhibition of thrombin formation by APC not only limits fibrin formation but also stimulates fibrinolysis by reducing TAFI activation. We evaluated the influence of prothrombin G20210A mutation on the anticoagulant and fibrinolytic activities of APC (1 microg/ml). Thirty-two...

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Identifiers

PMID: 16601829

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Hyperprothrombinaemia-induced APC resistance: differential influence on fibrin formation and fibrinolysis.PMID 16601829Read ↗

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Prothrombin fragment 1+2 and thrombin–antithrombin complex levels in patients with inherited APC resistance due to factor V Leiden mutationSemantic proximity Read ↗

Phenotypic APC resistance in carriers of the A20210 prothrombin mutation is associated with an increased risk of venous thrombosis.Semantic proximity Read ↗

Prothrombin activity and concentration in healthy subjects with and without the prothrombin G20210A mutation.Semantic proximity Read ↗

Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.Semantic proximity Read ↗

No effect of the prothrombin G20210A mutation on protein C activation in a large kindred with type I protein C deficiency.Semantic proximity Read ↗

Routine coagulation tests are not useful as a screening tool for the FII G20210A polymorphism.Semantic proximity Read ↗

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