Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

doi:10.1074/jbc.270.36.21158

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Article

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.

The Journal of biological chemistry - 8 Sept 1995

Nicolaes G A, Tans G, Thomassen M C, Hemker H C, Pabinger I, Varadi K, Schwarz H P, Rosing J

Abstract excerpt

Factor V was purified from the plasma of an activated protein C (APC)-resistant patient who is homozygous for the mutation Arg506-->Gln (factor VR506Q). Factor VR506Q was converted by thrombin into factor Va which was further purified yielding a factor Va preparation that had the same cofactor ac...

Topics

Arginine
Blotting, Western
Catalysis
Cell Membrane
Factor Va
Glycine
Humans
Hydrolysis
Kinetics
Mutation
Peptides
Phospholipids
Protein C
Prothrombin

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