Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.

The Journal of biological chemistry - 20 Oct 2006

Norstrøm Eva A, Tran Sinh, Steen Mårten, Dahlbäck Björn

Abstract excerpt

Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the individual cleavage sites...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Chemical
Share to Arginine
Share to Factor Xa

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kinetics

Share to Phospholipids

Share to Protein C

Share to Protein S

Share to Recombinant Proteins

Source

Identifiers

PMID: 16935856
DOI: 10.1074/jbc.M606441200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.PMID 16935856Read ↗

Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.Semantic proximity Read ↗

Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.Semantic proximity Read ↗

Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.Semantic proximity Read ↗

Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.Semantic proximity Read ↗

Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.Semantic proximity Read ↗

Inhibition of thrombin formation by active site mutated (S360A) activated protein C.Semantic proximity Read ↗

Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.Semantic proximity Read ↗

Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.Semantic proximity Read ↗

Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency.Semantic proximity Read ↗

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.Semantic proximity Read ↗

A sequential mechanism for exosite-mediated factor IX activation by factor XIa.Semantic proximity Read ↗

Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.