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Article

Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder.

Psychiatric genetics - 1 Feb 2008

Amano Kenji, Yamada Kazuo, Iwayama Yoshimi, Detera-Wadleigh Sevilla D, Hattori Eiji, Toyota Tomoko, Tokunaga Katsushi, Yoshikawa Takeo, Yamakawa Kazuhiro

Abstract excerpt

OBJECTIVES: Defects of neurodevelopmental processes are suggested to underlie the pathogenesis of bipolar disorder. Down syndrome cell adhesion molecule (DSCAM), a member of neural immunoglobulin superfamily playing a diverse role for neural development, is mapped to chromosome 21q22, a linkage locus for bipolar disorder, and is, therefore, an interesting candidate for the disease. METHODS: We performed a...

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Source

Identifiers

PMID: 18197079
DOI: 10.1097/YPG.0b013e3281ac238e

Genes

DSCAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder.PMID 18197079Read ↗

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Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.Semantic proximity Read ↗

Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesionSemantic proximity Read ↗

Potential involvement of DSCAML1 mutations in neurodevelopmental disorders.Semantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndromeSemantic proximity Read ↗

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse modelsSemantic proximity Read ↗

Biallelic loss-of-function variants in DSCAM cause a neurodevelopmental syndrome with nystagmus and retinal dysfunction.Semantic proximity Read ↗

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