Article
Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals.
Biological psychiatry - 15 Apr 2004
Arai Makoto, Itokawa Masanari, Yamada Kazuo, Toyota Tomoko, Arai Mayumi, Haga Seiichi, Ujike Hiroshi, Sora Ichiro, Ikeda Kazuhiko, Yoshikawa Takeo
Abstract excerpt
BACKGROUND: Although the pathogenesis of mood disorders remains unclear, heritable factors have been shown to be involved. Neural cell adhesion molecule 1 (NCAM1) is known to play important roles in cell migration, neurite growth, axonal guidance, and synaptic plasticity. Disturbance of these neurodevelopmental processes is proposed as one etiology for mood disorder. We therefore undertook genetic analysis of...
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