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Article

Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma

1 Jan 2008

Abstract excerpt

Promoter region hypermethylation and transcriptional silencing is a frequent cause of tumour suppressor gene (TSG) inactivation in many human cancers. Previously, to identify candidate epigenetically inactivated TSGs in renal cell carcinoma (RCC), we monitored changes in gene expression in four RCC cell lines after treatment with the demethylating agent 5-azacytidine. This enabled us to identify HAI-2/SPINT2 as a...

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Share to Epigenetics and DNA Methylation
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PMID: 18195710
DOI: 10.1038/sj.bjc.6604180

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