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Article

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

13 Sept 2013

Abstract excerpt

BACKGROUND: Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation of the VHL tumour suppressor gene (TSG), inactivation of chromosome 3p TSGs implicated in chromatin modification and remodelling and de novo tumour-specific promoter methylation of renal TSGs....

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PMID: 24034811
DOI: 10.1186/1868-7083-5-16

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