Article
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 2008
Yauk Carole, Polyzos Aris, Rowan-Carroll Andrea, Somers Christopher M, Godschalk Roger W, Van Schooten Frederik J, Berndt M Lynn, Pogribny Igor P, Koturbash Igor, Williams Andrew, Douglas George R, Kovalchuk Olga
Abstract excerpt
Particulate air pollution is widespread, yet we have little understanding of the long-term health implications associated with exposure. We investigated DNA damage, mutation, and methylation in gametes of male mice exposed to particulate air pollution in an industrial/urban environment. C57BL/CBA mice were exposed in situ to ambient air near two integrated steel mills and a major highway, alongside control mice...
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