Article
Molecular and organismal changes in offspring of male mice treated with chemical stressors.
Environmental and molecular mutagenesis - 1 Jun 2012
Shiao Yih-Horng, Leighty Robert M, Wang Cuiju, Ge Xin, Crawford Erik B, Spurrier Joshua M, McCann Sean D, Fields Janet R, Fornwald Laura, Riffle Lisa, Driver Craig, Kasprzak Kazimierz S, Quiñones Octavio A, Wilson Ralph E, Travlos Gregory S, Alvord W Gregory, Anderson Lucy M
Abstract excerpt
Both gene methylation changes and genetic instability have been noted in offspring of male rodents exposed to radiation or chemicals, but few specific gene targets have been established. Previously, we identified the gene for ribosomal RNA, rDNA, as showing methylation change in sperm of mice treated with the preconceptional carcinogen, chromium(III) chloride. rDNA is a critical cell growth regulator. Here, we...
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