Article
Glucocorticoid receptor gene and risk of cardiovascular disease.
Archives of internal medicine - 14 Jan 2008
van den Akker Erica L T, Koper Jan W, van Rossum Elisabeth F C, Dekker Marieke J H, Russcher Henk, de Jong Frank H, Uitterlinden Andre G, Hofman Albert, Pols Huibert A, Witteman Jacqueline C M, Lamberts Steven W J
Abstract excerpt
BACKGROUND: Genetic variants in immunomodulating genes have been suggested to contribute to the risk of cardiovascular disease. Glucocorticoids are important regulators of inflammatory processes and the immune system. Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease. METHODS: The study was conducted...
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