Article
ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines.
Journal of cellular and molecular medicine - 1 Dec 2008
Shen H, Luan F, Liu H, Gao L, Liang X, Zhang L, Sun W, Ma C
Abstract excerpt
The zinc-fingers and homeoboxes 2 (ZHX2) protein was shown previously to be involved in postnatal repression of alpha-fetoprotein (AFP) in mice. More recently, loss of ZHX2 expression was often found in human hepatcellular carcinoma (HCC), where AFP is frequently reactivated. Using HepG2 and HepG2.2.15, which express high AFP levels, we show that ZHX2 overexpression significantly decreases of AFP secretion in a...
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