Article
Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma.
The international journal of biochemistry & cell biology - 1 Oct 2014
Luan Fang, Liu Peng, Ma Hongxin, Yue Xuetian, Liu Jun, Gao Lifen, Liang Xiaohong, Ma Chunhong
Abstract excerpt
Glypican 3 (GPC3) has been paid particular attention owing to its potential as diagnosis marker for hepatocellular carcinoma (HCC). Identifying the mechanisms regulating the reactivation of GPC3 in HCC appears to be clinically meaningful. Previous study identified zinc-fingers and homeoboxes 2 (ZHX2) as transcriptional factor responsible for postnatal repression of GPC3 in mice. Here, in this study, we provided...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.