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Article

The functional R620W variant of the PTPN22 gene is associated with celiac disease.

Tissue antigens - 1 Mar 2008

Santin I, Castellanos-Rubio A, Aransay A M, Castaño L, Vitoria J C, Bilbao J R

Abstract excerpt

The functional (R620W) variant of human PTPN22 (protein tyrosine phosphatase non-receptor 22) gene has been implicated in the risk to several autoimmune disorders, including type 1 diabetes, Graves' disease, rheumatoid arthritis and systemic lupus erythematosus. In an association study of this single nucleotide polymorphism with celiac disease (CD), comparison of 262 young diagnosis patients and 214 adult...

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18194365
DOI: 10.1111/j.1399-0039.2007.01002.x

Genes

PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The functional R620W variant of the PTPN22 gene is associated with celiac disease.PMID 18194365Read ↗

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?Semantic proximity Read ↗

C1858T functional variant of PTPN22 gene is not associated with celiac disease genetic predisposition.Semantic proximity Read ↗

Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease.Semantic proximity Read ↗

PTPN22: setting thresholds for autoimmunity.Semantic proximity Read ↗

Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.Semantic proximity Read ↗

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