Article
Association of PTPN22 Single Nucleotide Polymorphisms with Celiac Disease.
Fetal and pediatric pathology - 1 Jun 2017
Aflatounian Majid, Rezaei Arezou, Sadr Maryam, Saghazadeh Amene, Elhamian Nazanin, Sadeghi Hengameh, Motevasselian Fatemeh, Farahmand Fatemeh, Fallahi Gholamhossein, Motamed Farzaneh, Najafi Mehri, Rezaei Nima
Abstract excerpt
OBJECTIVES: Celiac disease is a chronic autoimmune disease in which gene-environment interactions cause the immune system to unfavorably react to naturally gluten-containing foods. PTPN22 plays a crucial role in regulating the function of various cells of the immune system, particularly T cells. Polymorphisms of the PTPN22 gene have been associated with many autoimmune diseases. The present genetic association...
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