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Article

The role of the ZEB family of transcription factors in development and disease.

Cellular and molecular life sciences : CMLS - 1 Mar 2009

Vandewalle C, Van Roy F, Berx G

Abstract excerpt

The ZEB family of zinc finger transcription factors are essential players during normal embryonic development. One characteristic is that they induce epithelial to mesenchymal transition (EMT), a process that reorganizes epithelial cells to become migratory mesenchymal cells. E-cadherin is a major target gene of these transcriptional repressors, and this downregulation is considered a hallmark of EMT. In recent...

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Identifiers

PMID: 19011757
DOI: 10.1007/s00018-008-8465-8
PMCID: PMC11131515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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