Article
SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system.
The EMBO journal - 23 Jan 2008
Weake Vikki M, Lee Kenneth K, Guelman Sebastián, Lin Chia-Hui, Seidel Christopher, Abmayr Susan M, Workman Jerry L
Abstract excerpt
Nonstop, which has previously been shown to have homology to ubiquitin proteases, is required for proper termination of axons R1-R6 in the optic lobe of the developing Drosophila eye. Herein, we establish that Nonstop actually functions as an ubiquitin protease to control the levels of ubiquitinated histone H2B in flies. We further establish that Nonstop is the functional homolog of yeast Ubp8, and can substitute...
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