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Article

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging.

eLife - 25 Feb 2021

Erez Neta, Israitel Lena, Bitman-Lotan Eliya, Wong Wing H, Raz Gal, Cornelio-Parra Dayanne V, Danial Salwa, Flint Brodsly Na'ama, Belova Elena, Maksimenko Oksana, Georgiev Pavel, Druley Todd, Mohan Ryan D, Orian Amir

Abstract excerpt

A hallmark of aging is loss of differentiated cell identity. Aged Drosophila midgut differentiated enterocytes (ECs) lose their identity, impairing tissue homeostasis. To discover identity regulators, we performed an RNAi screen targeting ubiquitin-related genes in ECs. Seventeen genes were identified, including the deubiquitinase Non-stop (CG4166). Lineage tracing established that acute loss of Non-stop in young...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33629655
DOI: 10.7554/eLife.62312
PMCID: PMC7936876

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